Name

PPA1; NGR003

Phenotype

Primary Progressive Aphasia (Autopsy Proven)

Inheritance

Familial

Onset Age

Mean: 62.0 years; Range: 60 - 65 years; 3 patients

Age at Death

Mean: 72.0 years; Range: 65 - 73 years

Disease Duration

Mean: 8.0 years; Range: 4 - 12 years

Ethnic origin

Caucasian (USA)

Mutation

GRN Gly333fs (Segregation Proven)

Citations

Krefft TA, Alzheimer Disease and Associated Disorders 17: 106-112, 2003
Gass J, Human Molecular Genetics 15: 2988-3001, 2006
Mesulam M, Archives of Neurology 64: 43-47, 2007
Finch N, Brain 132: 583-591, 2009
Kelley BJ, Neurobiology of Aging 30: 739-751, 2009

Added: September 8, 2006
Last Modified: March 20, 2008

ID: 616